#：corresponding author.

Independent Career:

26. Watching biomolecules stride in real time.

J Fei , R Zhou#. Science 379, 986-987 (2023)

25. Proteomic and functional analyses of the periodic membrane skeleton in neurons.

R Zhou# , B Han , R Nowak , Y Lu , E Heller , C Xia , AH Chishti , VM Fowler , X Zhuang#. Nature Communications 13, 3196 (2022)

Prior to Penn State:

Selected publications:

24. Membrane-associated periodic skeleton is a signaling platform for RTK transactivation in neurons.

R Zhou , B Han , C Xia , X Zhuang. Science 365, 929-934 (2019)

Highlighted in Nature Reviews Neuroscience 20, 647 (2019): A platform for coordinated signalling

23. Junction resolving enzymes use multivalency to keep the Holliday junction dynamic.

R Zhou# (co-corresponding author) , O Yang , AC Déclais et al. Nature Chemical Biology 15, 269-275 (2019)

Highlighted in Nature Chemical Biology 15, 209-210 (2019): Freedom of movement

22. Visualizing and discovering cellular structures with super-resolution microscopy.

Y Sigal , R Zhou , X Zhuang. Science 361, 880-887 (2018)

21. Structural organization of the actin-spectrin–based membrane skeleton in dendrites and soma of neurons

B Han , R Zhou# (co-first author / co-corresponding author) , C Xia , X Zhuang#. PNAS 114,6678-6685 (2017)

20. Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species.

J He , R Zhou (co-first author) , Z Wu et al. PNAS 113, 6029-6034 (2016)

19. Real-time imaging of translation on single mRNA transcripts in live cells.

C Wang , B Han , R Zhou , X Zhuang. Cell 165, 990-1001 (2016)

18. Asymmetric unwrapping of nucleosomes under tension directed by DNA local flexibility.

TTM Ngo , Q Zhang , R Zhou , JG Yodh and T Ha. Cell 160, 1135-1144 (2015)

Highlighted in Cell 160, 1139-1140 (2015): A Molecular Take on Aesop’s The Oak and the Reeds.

17. Periodic DNA patrolling underlies diverse functions of Pif1 on R-loops and G-rich DNA.

R Zhou , J Zhang , ML Bochman , VA Zakian and T Ha. eLife 3, e02190 (2014)

Highlighted in eLife 3, e02854 (2014): DNA Helicases: Molecular watchdogs on genome patrol

16. Detecting intramolecular conformational dynamics of single molecules in short distance range with sub-nanometer sensitivity.

R Zhou , S Kunzelmann , M Webb , T Ha. Nano Letters 11, 5482-5488 (2011)

15. SSB functions as a sliding platform that migrates on DNA via reptation.

R Zhou , AG Kozlov , R Roy , J Zhang , S Korolev , TM Lohman and T Ha. Cell 146, 222-232 (2011)

Selected as: the Cell PaperFlick (video) of the issue (Watch on Youtube)

14. Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics.

C Grashoff , BD Hoffman , MD Brenner , R Zhou , M Parsons , MT Yang , M A. McLean , SG Sligar , CS Chen , T Ha and MA Schwartz. Nature 466, 263–266 (2010)

Highlighted in Nature 466, 192–193 (2010): Sensing tension

13. Fluorescence-force spectroscopy maps two-dimensional reaction landscape of the Holliday junction.

S Hohng , R Zhou , MK Nahas , J Yu , K Schulten , DMJ Lilley and T Ha. Science 318, 279-283 (2007)

Highlighted in Nature Methods 4, 986-987 (2007): Fluorescence-force spectroscopy: watch your tether

Other publications:

12. βII-spectrin promotes mouse brain connectivity through stabilizing axonal plasma membranes and enabling axonal organelle transport.

DN Lorenzo , A Badea , R Zhou et al. PNAS 116, 15686-15695 (2019)

11. Spider silk peptide is a compact, linear nanospring ideal for intracellular tension sensing.

MD Brenner , R Zhou , et al. Nano Letters 16, 2096-2102 (2016)

10. Developmental mechanism of the periodic membrane skeleton in axons.

G Zhong , J He , R Zhou , D. Lorenzo , HP Babcock , V Bennett , X Zhuang. eLife 3, e04581 (2015)

9. Structural mechanisms of PriA-mediated DNA replication restart.

B Bhattacharyya , NP George , TM Thurmes , R Zhou , N Jani , SR Wessel , SJ Sandler , T Ha and JL Keck. PNAS 111, 1373-1378 (2014)

8. An improved surface passivation method for single-molecule studies.

B Hua , KY Han , R Zhou , H Kim , X Shi , SC Abeysirigunawardena , A Jain , D. Singh , V. Aggarwal , SA Woodson and T Ha. Nature Methods 11, 1233-1236 (2014)

7. The Telomere Capping Complex CST Has an Unusual Stoichiometry, Makes Multipartite Interaction with G-Tails, and Unfolds Higher-Order G-Tail Structures.

NF Lue , R Zhou , L Chico , N Mao , O Steinberg-Neifach and T Ha. PLoS Genetics 9, e1003145 (2013)

6. The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1.

SH Yang , R Zhou , J Campbell , J Chen , T Ha , and TT Paull. EMBO Journal 32, 126-132 (2013)

5. PriC-mediated DNA replication restart requires PriC complex formation with the single-stranded DNA-binding protein.

SR Wessel , AH Marceau , SC Massoni , R Zhou , T Ha , SJ Sandler and JL Keck. publisher of Biological Chemistry 288, 17569-17578 (2013)

4. Single molecule analysis of Thermus thermophilus SSB protein dynamics on single-stranded DNA.

J Zhang , R Zhou , J Inoue , T Mikawa , T Ha. Nucleic Acids Research 42, 3821-3832 (2013)

3. Single molecule analysis of SSB dynamics on DNA.

R Zhou , T Ha. Methods in Molecular Biology 922, 85-100 (2012)

2. Forcing a connection: Impacts of single-molecule force spectroscopy on in vivo tension sensing.

MD Brenner , R Zhou , and T Ha. Biopolymers 95, 332-344 (2011)

1. Fluorescence-force spectroscopy at the single molecule level.

R Zhou , M Schlierf , and T Ha. Methods in Enzymology 475C, 405-426 (2010)